NDLI: Pericyte-targeting drug delivery and tissue engineering

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Pericyte-targeting drug delivery and tissue engineering

Content Provider	Scilit
Author	Kang, Eunah Shin, Jong Wook
Copyright Year	2016
Description	Journal: International Journal of Nanomedicine Pericyte-targeting drug delivery and tissue engineering Eunah Kang,1 Jong Wook Shin2 1School of Chemical Engineering and Material Science, 2Division of Allergic and Pulmonary Medicine, Department of Internal Medicine, College of Medicine, Chung-Ang University, Dongjak-Gu, Seoul, South Korea Pericytes are contractile mural cells that wrap around the endothelial cells of capillaries and venules. Depending on the triggers by cellular signals, pericytes have specific functionality in tumor microenvironments, properties of potent stem cells, and plasticity in cellular pathology. These features of pericytes can be activated for the promotion or reduction of angiogenesis. Frontier studies have exploited pericyte-targeting drug delivery, using pericyte-specific peptides, small molecules, and DNA in tumor therapy. Moreover, the communication between pericytes and endothelial cells has been applied to the induction of vessel neoformation in tissue engineering. Pericytes may prove to be a novel target for tumor therapy and tissue engineering. The present paper specifically reviews pericyte-specific drug delivery and tissue engineering, allowing insight into the emerging research targeting pericytes. Keywords: pericytes, pericyte-targeting drug delivery, tissue engineering, platelet-derived growth factor, angiogenesis, vascular remodeling
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892861/pdf https://www.dovepress.com/getfile.php?fileID=30618
Ending Page	2406
Page Count	10
Starting Page	2397
e-ISSN	11782013
DOI	10.2147/ijn.s105274
Journal	International Journal of Nanomedicine
Volume Number	ume 11
Language	English
Publisher	Informa UK Limited
Publisher Date	2016-05-01
Access Restriction	Open
Subject Keyword	Journal: International Journal of Nanomedicine Agricultural Engineering Angiogenesis Pericyte-targeting Drug Delivery Platelet-derived Growth Factor Tissue Engineering Vascular Remodeling
Content Type	Text

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