Loading...
Please wait, while we are loading the content...
Similar Documents
Outcome of risk adapted therapy for relapsed/refractory acute lymphoblastic leukemia in children
| Content Provider | Scilit |
|---|---|
| Author | Belgaumi, Asim F. Al-Seraihy, Amal Siddiqui, Khawar S. Ayas, Mouhab Bukhari, Asem Al-Musa, Abdulrahman Al-Ahmari, Ali El-Solh, Hassan |
| Copyright Year | 2012 |
| Description | Journal: Leukemia & Lymphoma Results of second-line therapy for childhood acute lymphoblastic leukemia (ALL) remain suboptimal, particularly for high-risk groups identified using timing and site of relapse. We report results of prospectively collected data for pediatric patients with ALL who received risk adjusted second-line therapy. The 59 patients who failed first-line ALL therapy included 36 (61%) with bone marrow (BM), 13 (22.1%) with isolated extramedullary (EM) and 10 (16.9%) with BM + EM relapse. Some 51.8% patients were reinduced with high dose cytosine arabinoside (HDAraC)-based and 48.2% with standard four-drug regimens. In all, 38/56 (67.9%) achieved a complete remission (CR) with second-line therapy; the overall CR rate was 78.6% and was not associated with CR1 duration (p =0.8). Three-year overall survival (OS) was 45.3%, and was 61.4% for those achieving a CR. No risk group benefited from HSCT over chemotherapy. Patients with isolated EM relapse beyond 18 months of CR1 and BM relapse beyond 12 months off-therapy had an excellent outcome (OS 91.7%), identifying a particularly good-risk cohort. Patients not in this category continue with poor outcome even following hematopoietic stem cell transplant. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428194.2012.719616 |
| Ending Page | 554 |
| Page Count | 8 |
| Starting Page | 547 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2012.719616 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 3 |
| Volume Number | 54 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2013-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Research and Experimental Medicine Acute Lymphoblastic Leukemia |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
