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Outcome of childhood relapsed or refractory mature B-cell non-Hodgkin lymphoma and acute lymphoblastic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Anoop, Parameswaran Sankpal, Sushama Stiller, Charles Tewari, Sanjay Lancaster, Donna L. Khabra, Komel Taj, Mary M. |
| Copyright Year | 2012 |
| Description | Patients with childhood relapsed and refractory mature B-cell non-Hodgkin lymphoma (B-NHL) and acute lymphoblastic leukemia (B-ALL) are rare and have a dismal prognosis. The previous UK national analysis of 26 children over a 7-year period prior to 1996 had highlighted the poor outcome, with only three survivors. This 10-year multicenter study evaluated recent data, since 2000. Of 33 children, nine survived (27.3%), with a median follow-up of 4.3 years. On exclusion of six children treated with palliative intent, the survival was one-third (nine of 27; 33.3%). All patients with primary refractory disease (n = 7) and all except one with early relapse (n = 11) died. Administration of four doses of 375 mg/m2 of rituximab was associated with a longer survival (p = 0.006). Response to reinduction (p < 0.001) and autologous hematopoietic stem cell transplant (auto-HSCT) (p = 0.003) were significant on multivariate analysis. Patients with a time to relapse of at least 6 months are potentially curable and must be offered intensive treatment with salvage chemotherapy, rituximab and auto-HSCT. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428194.2012.677534 |
| Ending Page | 1888 |
| Page Count | 7 |
| Starting Page | 1882 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2012.677534 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 10 |
| Volume Number | 53 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2012-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Hematology Non-hodgkin Lymphoma Childhood Relapse Survival |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
