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Clinical characteristics and prognostic factors of primary extranodal classical Hodgkin lymphoma: a retrospective study
| Content Provider | Scilit |
|---|---|
| Author | Aliya Yang, Mingzi Ping, Lingyan Liu, Weiping Xie, Yan Liu, Yanfei Nuersulitan, Reyizha Zhu, Jun Wu, Meng Song, Yuqin |
| Copyright Year | 2019 |
| Description | Journal: Hematology Objectives: To analyze the clinical characteristics and prognosis of primary extranodal classical Hodgkin lymphoma (PE-cHL). Methods: Clinical features and outcomes of 22 PE-cHL patients who received initial chemotherapy January 2008 to January 2018 were analyzed retrospectively, and compared with 274 primary nodal Hodgkin lymphoma (PN-cHL) patients treated in the same period. Results: With a median follow-up period of 42 months, compared with 274 PN-cHL patients, no significant difference of overall response rate (ORR) or complete remission (CR) rate was found, but the PE-cHL patients showed a higher recurrence rate (36.4% vs. 13.1%, p = .003) and poorer survival [(5-year overall survival (OS) rate: 64.6% vs. 97.7%, p = .001; 5-year progression-free survival (PFS) rate: 42.4% vs. 82.2%, p < .001)]. To minimize the effects of confounding factors, PE-cHL patients were matched with PN-cHL patients at a ratio of 1:1 according to age, gender, histological types and stage. Compared with 22 matched PN-cHL cases, PE-cHL was still associated with poor PFS (5-year PFS: 42.4% vs. 79.9%, p = .004). As to 22 PE-cHL patients, univariate analysis showed elevated serum lactate dehydrogenase (LDH) and elevated platelet (PLT) were associated with poor PFS (p < .05). Discussion: Compared with PN-cHLs, PE-cHLs showed a considerable shorter duration of remission, higher recurrence tendency and poorer survival, indicating that more intensive therapy may be needed. Conclusion: The prognosis of PE-cHL is unfavorable. Elevated LDH and PLT are poor prognostic factors for PE-cHL. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/16078454.2019.1598678?needAccess=true |
| Ending Page | 419 |
| Page Count | 7 |
| Starting Page | 413 |
| ISSN | 10245332 |
| e-ISSN | 16078454 |
| DOI | 10.1080/16078454.2019.1598678 |
| Journal | Hematology |
| Issue Number | 1 |
| Volume Number | 24 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Hematology Hodgkin Lymphoma Primary Extranodal Clinical Characteristics Overall Survival Progression-free Survival Prognostic Factors |
| Content Type | Text |
| Subject | Hematology |
