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Clinical Significance of Red Cell Distribution Width and Circulating Tumor Cells with an Epithelial–Mesenchymal Transition Phenotype in Lung Adenocarcinoma
| Content Provider | Scilit |
|---|---|
| Author | Peng, Huajian Tan, Xiang Wang, Yongyong Dai, Lei Liang, Guanbiao Guo, Jianji Chen, Mingwu |
| Copyright Year | 2020 |
| Description | Journal: Cancer Management and Research Objective: To determine the prognostic value of red cell distribution width (RDW) and circulating tumor cells with epithelial–mesenchymal transition phenotype (M-CTC) in lung adenocarcinoma (LUAD). Patients and Methods: Clinical and laboratory data of 60 patients with LUAD were collected. CTCs were isolated from their peripheral blood using the $CanPatrol^{TM}$ CTC enrichment method. The indicators of RDW and neutrophil lymphocyte ratio (NLR) were calculated based on the laboratory standards. Results: A total of 60 LUAD patients were enrolled, of which 19 (31.7%) had high RDW (> 0.14) and 32 (53.3%) were positive for M-CTCs. There was no significant correlation between RDW and the clinical characteristics. M-CTC was not significantly associated with tumor size and differentiation, age, gender, tumor stage, and histological type but correlated significantly with lymphatic metastasis (P = 0.044), high NLR (> 2.26, P = 0.023), and high RDW (> 0.14, P = 0.036). Furthermore, the $M-CTC^{+}$ LUAD patients had a significantly poor recurrence-free survival (RFS; Log rank P =0.001, HR = 2.749, 95% CI = 1.489– 5.078) and overall survival (OS; Log rank P =0.022, HR = 2.283, 95% CI = 1.128– 4.622) compared to the $M-CTC^{−}$ patients. Similarly, high RDW also correlated with worse RFS (Log rank P = 0.008, HR = 2.331, 95% CI = 1.248– 4.353) and OS (Log rank P = 0.004, HR = 0.004, 95% CI = 1.398– 5.525). Conclusion: M-CTC is significantly related to RDW and NLR, and an independent prognostic factor in LUAD. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326696/pdf https://www.dovepress.com/getfile.php?fileID=59227 |
| Ending Page | 5117 |
| Page Count | 13 |
| Starting Page | 5105 |
| ISSN | 11791322 |
| DOI | 10.2147/cmar.s251271 |
| Journal | Cancer Management and Research |
| Volume Number | ume 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Management and Research Circulating Tumor Cell Epithelial–mesenchymal Lung Adenocarcinoma Red Cell Distribution Width |
| Content Type | Text |
| Subject | Oncology |
