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Physicochemical Properties of Indomethacin and Related Compounds Co-Spray Dried with Polyvinylpyrrolidone
| Content Provider | Scilit |
|---|---|
| Author | Corrigan, O. I. Holohan, E. M. Reilly, M. R. |
| Copyright Year | 1985 |
| Description | Journal: Drug Development and Industrial Pharmacy The spray drying of indomethacin produced a viscous liquid phase which then solidified to an amorphous glassy solid mass. This amorphous phase was physically unstable and converted on storage to crystalline indomethacin forms II and I. Co -spray drying indomethacin with up to 20% PVP also gave a fused amorphous solid. Apparent solubility and dissolution studies illustrated the higher energy of indomethacin in these systems. The presence of PVP in the solid retarded conversion of indomethacin to a crystalline phase, the effect increasing with increasing PVP content. Scanning electron microscopy revealed the growth, with time, of needle-like whiskers on the surface of the amorphous products. Co-spray drying indomethacin with more than 20% PVP resulted firstly in products composed of a fused network of spherical particles, then partially coalesced spheres and ultimately, above 25% PVP, in individual agglomerated microspherical particles. The spray drying of either naproxen, ketoprofen or ibuprofen did not result in the formation of an amorphous glassy solid, Co-spray drying with PVP led to reduced crystallinity; the size of the melting endotherm decreased with increasing PVP content and became absent at 50% PVP. As the PVP percentage increased a microspherical product also developed, but at PVP levels greater than that observed for indomethacin. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639048509056895 |
| Ending Page | 695 |
| Page Count | 19 |
| Starting Page | 677 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639048509056895 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 2-3 |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1985-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Coatings and Films Physicochemical Properties Compounds Co Related Compounds Polyvinylpyrrolidone Properties of Indomethacin |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
