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Powder Characteristics of Proteins Spray-Dried from Different Spray-Dryers
| Content Provider | Scilit |
|---|---|
| Author | Foster, Todd P. Leatherman, Michael W. |
| Copyright Year | 1995 |
| Description | Journal: Drug Development and Industrial Pharmacy The powder characteristics of bovine somatotropin and casein spray-dried from laboratory, pilot and production spray-dryers were investigated. The powder characteristics examined included particle size distribution and morphology; bulk density; and flowability as measured by angle of repose, compressibility index and shear cell indices. Morphology classification showed internal voidage, blowholes, expanded, smooth and folding for somatotropin and casein spray-dried from the various spray-dryers. Particle size distributions of the bovine somatotropin and casein were unimodal and skewed. As the drying-chamber size of the spray-dryer increased, the particle sizes of both somatotropin and casein increased from mean volume diameters of 6-8 μ using the laboratory and pilot spray-dryers to 13-24 μ when using the production size spray-dryers. Spray-dried bovine somatotropin and casein had bulk densities of 0.090 to 0.195 g/cm3. Three flowability tests showed casein and somatotropin spray-dried from the different spray-dryers exhibited poor flow which could result in pharmaceutical manufacture challenges. The morphology and flowability of the two spray-dried proteins remained the same when comparing material produced from all four spray-dryers. However, the mean volume diameter, particle size distribution and bulk density did vary which might change critical product characteristics during scale-up. In general, similar morphology, particle size distributions, flowability and bulk densities were observed when comparing spray-dried casein and bovine somatotropin produced from the same model spray-dryer. Casein is recommended as a model protein for powder characterization during spray-drying and early formulation manufacture process development when adequate quantities of the recombinant protein are not available. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049509069260 |
| Ending Page | 1723 |
| Page Count | 19 |
| Starting Page | 1705 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049509069260 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 15 |
| Volume Number | 21 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1995-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Powder Characteristics Different Spray Spray Dryers Proteins Spray Spray Dried |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
