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Tandem autologous versus autologous/allogeneic transplantation for multiple myeloma: propensity score analysis
| Content Provider | Scilit |
|---|---|
| Author | Kawamura, Koji Ikeda, Takashi Hagiwara, Shotaro Mori, Takehiko Shinagawa, Atsushi Nishiwaki, Kaichi Ohashi, Kazuteru Kubonishi, Shiro Fukuda, Takahiro Ito, Toshiro Tomita, Naoto Ichinohe, Tatsuo Kato, Koji Morishima, Yasuo Atsuta, Yoshiko Sunami, Kazutaka Kanda, Yoshinobu |
| Copyright Year | 2015 |
| Description | Journal: Leukemia & Lymphoma Autologous hematopoietic stem cell transplantation (auto-HCT) is considered a standard therapy for transplant-eligible patients with multiple myeloma, while allogeneic HCT (allo-HCT) is controversial. We retrospectively analyzed 765 patients with myeloma who underwent tandem transplantation between 1998 and 2012 using Japanese registry data. We evaluated the clinical outcomes of tandem auto-HCT (n = 676) and auto/allo-HCT (n = 89). To adjust for a selection bias, we compared overall survival (OS) between the two groups by a propensity score analysis. The probability of OS at six years was 58.5% for the tandem auto-HCT group and 54.4% for the tandem auto/allo-HCT group (p = 0.47). In a matched-pair analysis based on the propensity score, the difference in survival between the two groups was not statistically significant, although the survival curve appeared to reach a plateau beyond five years in the auto/allo group. Further strategies to reduce treatment-related mortality and enhance a graft-versus-myeloma effect are necessary to improve OS. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428194.2016.1154958 |
| Ending Page | 2083 |
| Page Count | 7 |
| Starting Page | 2077 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2016.1154958 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 9 |
| Volume Number | 57 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Allogeneic Transplantation Multiple Myeloma Novel Agents Propensity Score Analysis Tandem Autologous Transplantation |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
