NDLI: Genomic stratification of multiple myeloma treated with novel agents

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Genomic stratification of multiple myeloma treated with novel agents

Content Provider	Scilit
Author	Jiang, Allan Reece, Nna Chang, Hong
Copyright Year	2011
Description	Cytogenetic testing is now routinely performed for the prognostic work-up of multiple myeloma (MM). The abnormalities del(17p), t(4;14) and del(13q) have been established as predictors of poor outcome in patients with MM treated with conventional chemotherapy or stem cell transplant; chromosome 1q gains and 1p losses have also been identified as novel prognostic factors. In recent years, bortezomib and lenalidomide have emerged as effective treatments for both relapsed/refractory and newly diagnosed MM. However, the effect of cytogenetic abnormalities is unclear among patients with MM treated with these novel agents. Here we review recent studies that analyze the impact of specific genomic aberrations on the outcome of MM treated with bortezomib and/or lenalidomide.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/10428194.2011.608449
Ending Page	207
Page Count	6
Starting Page	202
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428194.2011.608449
Journal	Leukemia & Lymphoma
Issue Number	2
Volume Number	53
Language	English
Publisher	Informa UK Limited
Publisher Date	2011-09-19
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Hematology Cytogenetics Myeloma Prognostication
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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