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Daunorubicin-loaded magnetic nanoparticles of Fe3O4 overcome multidrug resistance and induce apoptosis of K562-n/VCR cells in vivo
| Content Provider | Scilit |
|---|---|
| Author | Chen, Bao-An Lai, Bin-Bin Cheng, Jian Xia, Guo-Hua Gao, Feng Xu, Wen-Lin Ding, Jia-Hua Gao, Chong Sun, Xin-Chen Xu, Cui-Rong Chen, Wen-Ji Chen, Ning-Na Liu, Li-Jie Li, Xiao-Mao Wang, Xue-Mei |
| Copyright Year | 2009 |
| Description | Journal: International Journal of Nanomedicine Daunorubicin-loaded magnetic nanoparticles of Fe3O4 overcome multidrug resistance and induce apoptosis of K562-n/VCR cells in vivo Bao-an Chen1, Bin-bin Lai1, Jian Cheng1, Guo-hua Xia1, Feng Gao1, Wen-lin Xu2, Jia-hua Ding1, Chong Gao1, Xin-chen Sun3, Cui-rong Xu1, Wen-ji Chen1, Ning-na Chen1, Li-jie Liu4, Xiao-mao Li5, Xue-mei Wang61Department of Hematology, 3Department of Oncology, the Affiliated Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People's Republic of China; 2Department of Hematology, the Affiliated People's Hospital, Jiangsu University, Zhenjiang, People's Republic of China; 4Institution of Physiology, 6State Key Lab of Bioelectronics (Chien-shiung Wu Laboratory), Southeast University, Nanjing, People's Republic of China; 5Department of Physics, University of Saarland, Saarbruechen, Germany Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy. We evaluated the effect of daunorubicin (DNR)-loaded magnetic nanoparticles of Fe3O4 (MNPs-Fe3O4) on K562-n/VCR cells in vivo. K562-n and its MDR counterpart K562-n/VCR cell were inoculated into nude mice subcutaneously. The mice were randomly divided into four groups: group A received normal saline, group B received DNR, group C received MNPs-Fe3O4, and group D received DNR-loaded MNPs-Fe3O4. For K562-n/VCR tumor, the weight was markedly lower in group D than that in groups A, B, and C. The transcriptions of Mdr-1 and Bcl-2 gene were significantly lower in group D than those in groups A, B, and C. The expression of Bcl-2 was lower in group D than those in groups A, B, and C, but there was no difference in the expression of P-glycoprotein. The transcriptions and expressions of Bax and caspase-3 in group D were increased significantly when compared with groups A, B, and C. In conclusion, DNR-loaded MNPs-Fe3O4 can overcome MDR in vivo.Keywords: multidrug-resistance reversal, leukemia, magnetic nanoparticles of Fe3O4, in vivo |
| Related Links | https://www.dovepress.com/getfile.php?fileID=5296 |
| Ending Page | 208 |
| Page Count | 8 |
| Starting Page | 201 |
| e-ISSN | 11782013 |
| DOI | 10.2147/IJN.S7287 |
| Journal | International Journal of Nanomedicine |
| Volume Number | 4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Nanomedicine Biomaterials Pharmacology and Pharmacy Multidrug-resistance Reversal Magnetic Nanoparticles of Fe3o4 |
| Content Type | Text |
