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Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
| Content Provider | Scilit |
|---|---|
| Author | Shen, Mingfang Chen, Baoan Cheng, Jian Gao, Feng Xu, Wenlin Shen, Huilin Ding, Jiahua Gao, Chong Sun, Qian Sun, Xinchen Cheng, Hongyan Li, Guohong Chen, Wenji Chen, Ningna Liu, Lijie Li, Xiaomao Wang, Xuemei |
| Copyright Year | 2009 |
| Description | Journal: International Journal of Nanomedicine Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells Baoan Chen1*, Jian Cheng1*, Mingfang Shen1, Feng Gao1, Wenlin Xu2, et al1Department of Hematology;2Department of Hematology, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, P.R China, et al *These authors have contributed equally to this work. Apoptosis is a common pathway that finally mediated the killing functions of anticancer drugs, which is an important cause of multidrug resistance (MDR). The aim of this study was to investigate the potential benefit of combination therapy with magnetic nanoparticle of Fe3O4 (MNP(Fe3O4)) and 5-bromotetrandrin (BrTet). Analysis of the apoptosis percentage showed that combination of daunorubicin (DNR) with either MNP(Fe3O4) or BrTet exerted a potent cytotoxic effect on K562/A02 cells, while MNP(Fe3O4) and BrTet cotreatment can synergistically enhance DNR-induced apoptosis. Importantly, we confirmed that the distinct synergism effect of that composite on reverse multidrug resistance may owe to the regulation of various proliferative and antiapoptotic gene products, including P53 and caspase-3. Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe3O4) and BrTet combination on CML.Keywords: K562/A02 leukemic cells, multidrug resistance, magnetic nanoparticle of Fe3O4, 5-bromotetrandrine, apoptosis, P53, caspase-3 |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720739/pdf https://www.dovepress.com/getfile.php?fileID=4611 |
| Ending Page | 71 |
| Page Count | 7 |
| Starting Page | 65 |
| e-ISSN | 11782013 |
| DOI | 10.2147/ijn.s5036 |
| Journal | International Journal of Nanomedicine |
| Volume Number | 4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Nanomedicine Agricultural Engineering K562/a02 Leukemic Cells Multidrug Resistance Magnetic Nanoparticle of Fe3o4 5-bromotetrandrine |
| Content Type | Text |
