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Angiotensinogen Gene Expression and Hypertension: Transgenic Animal Models
| Content Provider | Scilit |
|---|---|
| Author | Kalinyak, J. E. |
| Copyright Year | 2018 |
| Description | The renin-angiotensin system has always been viewed as an endocrine system involved in the feedback regulation of blood pressure and fluid-electrolyte homeostasis.$ ^{1} ^{–} ^{9}$ It has also been viewed as an atypical endocrine system, because the biologically active peptide, angiotensin II (AngII), is generated in the plasma. Angiotensinogen, predominantly synthesized and secreted into the circulation by the liver, is cleaved by renin, producing angiotensin I (AngI). AngI is subsequently cleaved by angiotensin-converting enzyme (ACE), producing AngII. AngII is the major biologically active peptide that binds to its receptors to stimulate the secretion of aldosterone or cause vasoconstriction of the vasculature.$ ^{1} ^{,} ^{3} ^{,} ^{10}$ Both of these actions are important in the maintenance of blood pressure routinely and in cases of hemorrhage.$ ^{11}$ AngII also increases arterial pressure by activating the sympathetic nervous system and by potentiating the norepinephrine responsiveness or release from nerve endings in blood vessels.$ ^{12} ^{–} ^{16}$ Book Name: Cellular and Molecular Biology of the Renin-Angiotensin System |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2017-0-66460-2&isbn=9781351070492&doi=10.1201/9781351070492-7&format=pdf |
| Ending Page | 179 |
| Page Count | 13 |
| Starting Page | 167 |
| DOI | 10.1201/9781351070492-7 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-01-18 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Cellular and Molecular Biology of the Renin-Angiotensin System Gene Expression Blood Pressure |
| Content Type | Text |
| Resource Type | Chapter |
