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Hormonal Regulation of the Angiotensinogen Gene in Liver and other Tissues
| Content Provider | Scilit |
|---|---|
| Author | Deschepper, C. F. Hong-Brown, L. Q. |
| Copyright Year | 2018 |
| Description | Angiotensinogen (AOG) is the glycoprotein precursor of the angiotensin peptides. It is cleaved by renin to yield the decapeptide angiotensin I (AngI); angiotensin-converting enzyme (ACE) then removes a dipeptide from the C-terminal end of AngI to form the physiologically active octapeptide angiotensin II (AngII). Circulating AngII increases vascular tone and promotes salt and water retention by a combined action on many target organs, including vascular smooth muscles, kidneys, adrenals, brain, and sympathetic nervous system. Both renin and AOG are rate-limiting factors in the generation of this important peptide.$ ^{1} ^{–} ^{3}$ The importance of maintaining adequate levels of AOG is underscored by the fact that its concentration in circulating plasma is close to the $K_{m}$ of the proteolytic activity of renin;$ ^{1} ^{,} ^{2} ^{,} ^{4}$ as a consequence, renin generates amounts of AngI that are directly proportional to the amounts of available substrate.$ ^{4} ^{,} ^{5}$ This observation has prompted many investigations aimed at delineating which factors control the production of AOG. Book Name: Cellular and Molecular Biology of the Renin-Angiotensin System |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2017-0-66460-2&isbn=9781351070492&doi=10.1201/9781351070492-6&format=pdf |
| Ending Page | 166 |
| Page Count | 18 |
| Starting Page | 149 |
| DOI | 10.1201/9781351070492-6 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-01-18 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Cellular and Molecular Biology of the Renin-Angiotensin System Glycoprotein Angiotensinogen |
| Content Type | Text |
| Resource Type | Chapter |
