NDLI: Liver Abnormalities in Penicillamine Treated Rheumatoid Arthritis

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Liver Abnormalities in Penicillamine Treated Rheumatoid Arthritis

Content Provider	Scilit
Author	Wollheim, Frank A. Lindström, Clas G.
Copyright Year	1979
Description	Journal: Scandinavian Journal of Rheumatology Liver enzymes were followed in 99 patients treated with D-penicillamine for rheumatoid arthritis. In six abnormalities were found which consisted of elevated levels of lactic dehydrogenase, ALAT/ASAT, alkaline phosphatases or combinations of these. The changes were reversible on stopping the drug with one possible exception. No evidence of biliary cirrhosis, chronic active hepatitis or HBag-dated hepatitis was found. Liver biopsy was performed in 4 cases–one was taken 2 months after the treatment was discontinued, and was normal. One biopsy showed mild inflammatory changes, whereas in two histologic evidence of toxic liver necrosis was present. Liver damage should be included among possible complications of D-PA treatment.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/03009747909108248
Ending Page	105
Page Count	6
Starting Page	100
ISSN	03009742
e-ISSN	15027732
DOI	10.3109/03009747909108248
Journal	Scandinavian Journal of Rheumatology
Issue Number	28
Volume Number	8
Language	English
Publisher	Informa UK Limited
Publisher Date	1979-01-01
Access Restriction	Open
Subject Keyword	Journal: Scandinavian Journal of Rheumatology Penicillamine Abnormalities
Content Type	Text
Subject	Immunology and Allergy Immunology Rheumatology

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