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OM-8980 and D-Penicillamine in the Treatment of Rheumatoid Arthritis:A 12-Month Double-blind Randomized Study
| Content Provider | Scilit |
|---|---|
| Author | Verstraeten, A. Sileghem, A. Dequeker, J. |
| Copyright Year | 1990 |
| Description | Journal: Scandinavian Journal of Rheumatology Forty patients with active rheumatoid arthritis were included in this monocentre double-blind study comparing the therapeutic efficacy and safety of the immunomodulator OM-8980 with that of D-penicillamine. After 12 months of treatment, the parameters of Ritchie index, duration of morning stiffness, pain assessed by a visual analogue scale and categories, number of swollen joints, grip strength and erythrocyte sedimentation rate (ESR) were all significantly improved with OM-8980, as was the case for the Ritchie index, number of swollen joints and ESR with D-penicillamine. Significant intergroup differences were recorded for pain categories in favour of OM-8980 and for the Ritchie index and number of swollen joints in favour of D-penicillamine. The need for concomitant anti-inflammatory therapies and the assessment of efficacy by physicians and patients did not differ significantly between the two groups. OM-8980 was significantly better tolerated than D-penicillamine (5 patients with 5 side effects as compared with 12 patients with 16 side effects). OM-8980 can thus be regarded as an efficient and well-tolerated slow-acting drug for the treatment of rheumatoid arthritis. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03009749009097631 |
| Ending Page | 431 |
| Page Count | 10 |
| Starting Page | 422 |
| ISSN | 03009742 |
| e-ISSN | 15027732 |
| DOI | 10.3109/03009749009097631 |
| Journal | Scandinavian Journal of Rheumatology |
| Issue Number | 6 |
| Volume Number | 19 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1990-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Scandinavian Journal of Rheumatology Rheumatology Rheumatoid Arthritis Penicillamine Swollen Joints Ritchie Index |
| Content Type | Text |
| Subject | Immunology and Allergy Immunology Rheumatology |
