NDLI: Induction of Helper t Cells by Pertussis Toxin During in Vlvo Priming to Insulin

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Induction of Helper t Cells by Pertussis Toxin During in Vlvo Priming to Insulin

Content Provider	Scilit
Author	Grenier-Brosette, N. Bettetini, D. Fehlmann, M. Cousin, J-L.
Copyright Year	1991
Description	Journal: Immunopharmacology and Immunotoxicology We have studied the effect of pertussis toxin (PT) on in vivo priming of T lymphocytes to insulin. Mice were immunized with bovine insulin in complete Freund's adjuvant and antigen-specific DNA synthesis was measured in lymphoid cell suspensions from lymph nodes and spleens. Insulin-specific response was greatly enhanced both in spleen and lymph nodes if mice were given PT at the time of immunization. Mice given PT presented 3 times more cells in spleen and 4 times less in lymph nodes. However, the major antigen-specific response was still observed in lymph nodes. PT had a strong mitogenic effect in vitro on lymph node cells but a weak effect on spleen cells indicating that the adjuvant activity of PT involves other effects besides the mitogenic activity.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/08923979109019692
Ending Page	86
Page Count	14
Starting Page	73
ISSN	08923973
e-ISSN	15322513
DOI	10.3109/08923979109019692
Journal	Immunopharmacology and Immunotoxicology
Issue Number	1-2
Volume Number	13
Language	English
Publisher	Informa UK Limited
Publisher Date	1991-01-01
Access Restriction	Open
Subject Keyword	Journal: Immunopharmacology and Immunotoxicology Infectious Diseases Pertussis Toxin Immunization Mitogenic Effect
Content Type	Text
Subject	Immunology and Allergy Toxicology Pharmacology Immunology

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