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Induction Chemotherapy with Versus Without Hormonal Synchronisation in Locally Advanced Breast Cancer
| Content Provider | Scilit |
|---|---|
| Author | Sjövall, Margareta Palm Malmström, Per |
| Copyright Year | 1997 |
| Description | Journal: Acta Oncologica Sixty-nine patients with locally advanced breast cancer were given induction chemotherapy with doxorubicin and cyclophosphamide (day 1) followed by methotrexate and 5-Fu (day 8). Thirty-two of these patients were also given tamoxifen (days 2-6) in an attempt to induce a Gl arrest in cancer cells, and oestrogen (days 7-8) to stimulate proliferation and thus induce a synchronized wave of proliferating cells. The induction therapy response rate was 61% in the series as a whole (n = 69), but was found to be significantly better in the group on the tamoxifen/oestrogen synchronization regimen than in the remainder on chemotherapy alone (82% vs. 43%). This difference was particularly marked in the respective receptor-positive subgroups [90% (9/10) vs. 30% (3/10); p< 0.001]. The findings suggest that, in combination with chemotherapy, tamoxifen/oestrogen therapy, given in the sequence outlined here, constitutes a promising regimen for the treatment of locally advanced receptor-positive breast cancer patients. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/02841869709109231 |
| Ending Page | 212 |
| Page Count | 6 |
| Starting Page | 207 |
| ISSN | 0284186X |
| e-ISSN | 1651226X |
| DOI | 10.3109/02841869709109231 |
| Journal | Acta Oncologica |
| Issue Number | 2 |
| Volume Number | 36 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1997-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Oncologica Breast Cancer Locally Advanced Induction Chemotherapy Advanced Breast Hormonal Synchronisation |
| Content Type | Text |
| Subject | Radiology, Nuclear Medicine and Imaging Hematology Oncology |
