NDLI: Second Line Hormonal Therapy with Aminoglutethimide in Metastatic Breast Cancer

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Second Line Hormonal Therapy with Aminoglutethimide in Metastatic Breast Cancer

Content Provider	Scilit
Author	Brufman, G. Biran, S.
Copyright Year	1990
Description	Journal: Acta Oncologica One hundred and twenty patients with metastatic breast cancer, whose disease progressed on hormonal therapy with tamoxifen, were treated with aminoglutethimide. The overall response rate was 34% and the median duration of response 9.5 months. Response to aminoglutethimide was achieved in all metastatic sites except lung and brain. Even 25% of patients who had failed to respond to prior tamoxifen did respond objectively to aminoglutethimide. The actuarial survival for all patients at 30 months was 22%. Although initial toxicity was high (70%), side effects of aminoglutethimide were transient, and treatment had to be discontinued in only four patients. The results of this trial confirm that aminoglutethimide is an effective treatment in metastatic breast cancer.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/02841869009092989
Ending Page	720
Page Count	4
Starting Page	717
ISSN	0284186X
e-ISSN	1651226X
DOI	10.3109/02841869009092989
Journal	Acta Oncologica
Issue Number	6
Volume Number	29
Language	English
Publisher	Informa UK Limited
Publisher Date	1990-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Oncologica Aminoglutethimide Metastatic Breast Line Hormonal Therapy
Content Type	Text
Subject	Radiology, Nuclear Medicine and Imaging Hematology Oncology

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