NDLI: Age-related changes of calpain II and α-crystallin in the lens of hereditary cataract (Nakano) mouse

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Age-related changes of calpain II and α-crystallin in the lens of hereditary cataract (Nakano) mouse

Content Provider	Scilit
Author	Yoshida, Haruko Murachi, Takashi Tsukahara, Isamu
Copyright Year	1985
Description	Journal: Current Eye Research The age-related changes of calpain II (high-Ca2++-requiring form of Ca2++-dependent cysteine proteinase; EC 3.4.22.17) and α-crystallin in the lens of hereditary cataract (Nakano; cac/cac) mouse were studied. Before the onset of the cataract formation, i.e. at the end of the 2nd week after birth, the calpain activity in Nakano mice was as high as that in the control ICR mice, but it decreased rapidly as the cataract progressed to completion during the 4th and the 12th week. Marked degradation of lens proteins ensued between the 2nd and the 4th weeks, and one of these proteins was identified, using monospecific antibodies, as B chain of α-crystallin. A chain of α-crystallin was not degraded in vivo in contrast to its known susceptibility to calpain in vitro. The present data suggest that in Nakano mice, calpain may be involved in the onset or early stage of the cataract formation.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/02713689509000005
Ending Page	988
Page Count	6
Starting Page	983
ISSN	02713683
e-ISSN	14602202
DOI	10.3109/02713689509000005
Journal	Current Eye Research
Issue Number	9
Volume Number	4
Language	English
Publisher	Informa UK Limited
Publisher Date	1985-01-01
Access Restriction	Open
Subject Keyword	Journal: Current Eye Research Hereditary Cataract
Content Type	Text
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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