Loading...
Please wait, while we are loading the content...
Effects of ethyl-α-d-glucoside on human dermal fibroblasts
| Content Provider | Scilit |
|---|---|
| Author | Bogaki, Takayuki Mitani, Keiichi Oura, Yuki Ozeki, Kenji |
| Copyright Year | 2017 |
| Description | Journal: Bioscience, Biotechnology, and Biochemistry Ethyl α-d-glucoside (α-EG) is a glycoside present in sake, Japanese rice wine. Previous studies have reported that α-EG suppresses skin roughness after ultraviolet B irradiation, transepidermal water loss, and hepatic function disorder, and has a skin moisturizing effect. In this study, 0.48 μM of α-EG was found to increase the proliferation of normal human dermal fibroblasts (NHDF) by 121.0%, and the amount of collagen I produced by NHDF increased by 159.6% at an α-EG concentration of 0.048 μM, compared to those in cells cultured without α-EG. In NHDF cultured in α-EG-supplemented medium, the expression of fibroblast growth factor I and VII mRNA increased by 148.8 and 153.1%, at an α-EG concentration of 4.8 and 0.048 μM, respectively, as measured by a quantitative reverse transcription-polymerase chain reaction. Transcript levels of type I collagen genes, COL1A1 and COL1A2, increased by 152.4 and 129.7%, respectively, and that of a type III collagen gene, COL3A1, increased by 131.8% at an α-EG concentration of 0.48 μM. These findings supported the possibility that α-EG was involved in the maintenance and improvement of skin homeostasis and moisturizing functions. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/09168451.2017.1353400?needAccess=true |
| Ending Page | 1711 |
| Page Count | 6 |
| Starting Page | 1706 |
| ISSN | 09168451 |
| e-ISSN | 13476947 |
| DOI | 10.1080/09168451.2017.1353400 |
| Journal | Bioscience, Biotechnology, and Biochemistry |
| Issue Number | 9 |
| Volume Number | 81 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2017-09-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Bioscience, Biotechnology, and Biochemistry Cell Proliferation Ethyl-α-d-glucoside Gene Expression Human Dermal Fibroblasts |
| Content Type | Text |
| Subject | Organic Chemistry Medicine Analytical Chemistry Molecular Biology Biochemistry Applied Microbiology and Biotechnology Biotechnology |
