NDLI: A calcium-based model of human lead kinetics

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A calcium-based model of human lead kinetics

Content Provider	Scilit
Author	O’Flaherty, Ellen J.
Copyright Year	2020
Description	Lead is a bone-seeking element. Early studies ( 6 , 7 ) showed that during chronic exposure, lead is gradually fixed in the crystalline matrix of bone. Over 90% of total body lead in adult humans is found in the skeleton ( 4 ). It was at one time believed that only very limited amounts of lead were capable of returning from bone to blood. However, Rabinowitz et al. ( 35 ) noted that the existence of an internal long-lived source of lead tracer could be inferred from the changing rate of loss of tracer from the blood of adult humans following a period of ingestion of a stable isotope of lead substituted in the diet. In addition, the experience of the lead industries with the Occupational Safety and Health Administration mandate instituted in 1978 ( 38 ), under which workers were removed from high lead exposure positions to low lead exposure positions when their blood lead concentrations had reached certain specified trigger levels, clearly demonstrated that failure to reduce blood lead concentrations much below 45 μg/dl during the prescribed 18-month removal period in those workers with high lead exposure of long duration must have been due to a continuous and substantial influx of bone lead into the blood ( 32 ). Book Name: Kinetic Models of Trace Element and Mineral Metabolism during Development
Related Links	https://content.taylorfrancis.com/books/download?dac=C2006-0-08470-4&isbn=9780367811716&doi=10.1201/9780367811716-22&format=pdf
Ending Page	231
Page Count	11
Starting Page	221
DOI	10.1201/9780367811716-22
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-01-29
Access Restriction	Open
Subject Keyword	Book Name: Kinetic Models of Trace Element and Mineral Metabolism during Development
Content Type	Text
Resource Type	Chapter

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