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Treatment of Relapsed Langerhans Cell Histiocytosis by Cyclosporin a Combined with Etoposide and Prednisone
| Content Provider | Scilit |
|---|---|
| Author | Körholz, Dieter Janßen, Cisela Göbel, Ulrich |
| Copyright Year | 1997 |
| Description | Journal: Pediatric hematology and oncology Optimal treatment for Langerhans cell histiocytosis (LCH) has not yet been established. High-risk patients with systemic LCH may have a fatal course of the disease despite intensive treatment. New approaches using cyclosporin A (CSA) showed promising results. Here, we report on a 4-year-old boy who presented with systemic LCH of skin, liver, bone, bone marrow, and soft tissue infiltrates. The patient was refractory to conventional therapy including VP16, prednisone, 6-mercaptopurine, methotrexate, and vinblastine. Therefore the patient was treated with CSA as continuous therapy (serum levels were kept between 300 and 400 ng/mL) as well as intensification with VP16 and prednisone every 4 weeks. As early as 4 months after starting this treatment, clinical symptoms completely disappeared except for a slightly enlarged liver. During the next 12 months all clinical symptoms except a limited skin involvement vanished although treatment with VP16 and prednisone was stopped and CSA serum levels were kept between 100 and 150 ng/mL. In conclusion, intensive therapy using high-dose CSA combined with VP16 and prednisone might be a therapeutic option for patients with otherwise refractory LCH. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/08880019709028774 |
| Ending Page | 449 |
| Page Count | 7 |
| Starting Page | 443 |
| ISSN | 08880018 |
| e-ISSN | 15210669 |
| DOI | 10.3109/08880019709028774 |
| Journal | Pediatric hematology and oncology |
| Issue Number | 5 |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1997-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Pediatric hematology and oncology Pediatrics and Child Health Chemotherapy Cyclosporin A Histiocytosis |
| Content Type | Text |
| Subject | Hematology Pediatrics, Perinatology and Child Health Oncology |
