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Treatment of Relapsed Precursor-B Acute Lymphoblastic Leukemia With Intensive Chemotherapy
| Content Provider | Scilit |
|---|---|
| Author | Kelly, Michael E. Lu, Xiaomin Devidas, Meenakshi Camitta, Bruce Abshire, Thomas Bernstein, Mark L. Billett, Amy Homans, Alan Sandler, Eric Buchanan, George |
| Copyright Year | 2013 |
| Description | Journal: Journal of pediatric hematology/oncology Pediatric patients who experience a bone marrow relapse of precursor-B acute lymphoblastic leukemia are cured <50% of the time. This study was designed to determine if intensification of therapies with known activity in this disease would improve the cure rates for patients with relapsed acute lymphoblastic leukemia. Patients were treated with intensive asparaginase during induction followed by repeated cycles of ifosfamide/etoposide and cytarabine/idarubicin. Patients with well-matched related donors were encouraged to undergo hematopoietic stem cell transplant as consolidation. The results of this study demonstrate no significant difference in disease-free survival in patients who received chemotherapy alone (45%) or chemotherapy followed by allogeneic stem cell transplant (50%). Furthermore, results from this study show no significant difference in event-free survival (39.9%±6.2%) or overall survival (41.6%±6.1%) at 8 years when compared with previous studies using less intensive regimens. Our results suggest that alternative therapies are needed to improve cure rates for pediatric patients with relapsed leukemia. |
| Related Links | http://europepmc.org/articles/pmc3957178?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957178/pdf |
| Ending Page | 513 |
| Page Count | 5 |
| Starting Page | 509 |
| ISSN | 10774114 |
| e-ISSN | 15363678 |
| DOI | 10.1097/mph.0b013e31829f3235 |
| Journal | Journal of pediatric hematology/oncology |
| Issue Number | 7 |
| Volume Number | 35 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of pediatric hematology/oncology Relapsed Precursor-b, All, Intensive Chemotherapy, Pog Study 9411, Simal 9 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Pediatrics, Perinatology and Child Health Oncology |
