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Role of Proteoglycans in Calcification
| Content Provider | Scilit |
|---|---|
| Author | Shepard, Nora |
| Copyright Year | 2020 |
| Description | Endochondral bone formation encompasses a complex, sequential series of events, all of which are fundamental to the normal development, growth, and the repair of the skeleton. The features of this process are perhaps best typified within growth plate cartilage, where all stages are simultaneously expressed (Figure 1). It is known that in early stages of plate cell development, chondrocytes divide and actively produce an extracellular matrix (proliferative zone) and within the lower hypertrophic zone, this matrix $calcifies.^{ 1,2 }$ The calcified matrix is then partially resorbed by invading vascular elements (zone of vascular invasion), and in due course, osteoblasts begin to elaborate osteoid upon reminant spicules of calcified cartilage, thus bringing to completion a complex process which terminates in bone formation. It is the calcification of cartilage within the extracellular matrix of growth plate cartilage which is the concern of this chapter. Figure 1 Growth plate cartilage from 2-week-old rat stained in situ with toluidine blue, showing all zones. (PZ, proliferating zone; HZ, hypertrophic zone.) Note the enhanced staining (arrow) in the calcified, longitudinal septa. Original magnification × 370. Book Name: Calcification in Biological Systems |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2006-0-01291-8&isbn=9781003068396&doi=10.1201/9781003068396-4&format=pdf |
| Ending Page | 58 |
| Page Count | 18 |
| Starting Page | 41 |
| DOI | 10.1201/9781003068396-4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-07-24 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Calcification in Biological Systems Calcification Bone Formation Hypertrophic |
| Content Type | Text |
| Resource Type | Chapter |
