NDLI: Systematic review of human gut resistome studies revealed variable definitions and approaches

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Systematic review of human gut resistome studies revealed variable definitions and approaches

Content Provider	Scilit
Author	Ho, Jeffery Yeoh, Yun Kit Barua, Nilakshi Chen, Zigui Lui, Grace Wong, Sunny H. Yang, Xiao Chan, Martin Cw Chan, Paul Ks Hawkey, Peter M. Ip, Margaret
Copyright Year	2020
Description	Journal: Gut Microbes In this review, we highlight the variations of gut resistome studies, which may preclude comparisons and translational interpretations. Of 22 included studies, a range of 12 to 2000 antibiotic resistance (AR) genes were profiled. Overall, studies defined a healthy gut resistome as subjects who had not taken antibiotics in the last three to 12 months prior to sampling. In studies with de novo assembly, AR genes were identified based on variable nucleotide or amino acid sequence similarities. Different marker genes were used for defining resistance to a given antibiotic class. Validation of phenotypic resistance in the laboratory is frequently lacking. Cryptic resistance, collateral sensitivity and the interaction with repressors or promotors were not investigated. International consensus is needed for selecting marker genes to define resistance to a given antibiotic class in addition to uniformity in phenotypic validation and bioinformatics pipelines.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/19490976.2019.1700755?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524153/pdf
ISSN	19490976
e-ISSN	19490984
DOI	10.1080/19490976.2019.1700755
Journal	Gut Microbes
Issue Number	1
Volume Number	12
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-11-09
Access Restriction	Open
Subject Keyword	Journal: Gut Microbes Biochemistry and Molecular Biology Antibiotic Resistance Gut Microbiota Meta-genomics Fecal Microbiota Transplantation
Content Type	Text
Subject	Infectious Diseases Gastroenterology Microbiology Microbiology (medical)

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