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Incidence and Clinical Significance of $CDKN2/MTS1/P16^{ink4A}$ND $MTS2/P15^{ink4B}$Gene Deletions in Childhood Acute Lymphoblastic Leukemia
| Content Provider | Scilit |
|---|---|
| Author | Zhou, Muxiang Gu, Lubing Yeager, Andrew M. Findley, Harry W. |
| Copyright Year | 1997 |
| Description | Journal: Pediatric hematology and oncology We have examined the incidence and clinical significance of deletions of two candidate tumor suppressor genes, $CDKN2/MTS1/p16^{ink4A}$ and $MTS2/p15^{ink4B}$, in pediatric acute lymphoblastic leukemia (ALL). Gene deletion was evaluated in leukemic bone marrow (BM) cells obtained at diagnosis from 105 pediatric ALL patients: 83 with B-cell precursor (BCP-ALL) ALL and 22 with T-ALL. CDKN2/p16 deletion was seen in 23 of the 83 (28%) BCP-ALL and 15 of the 22 (68%) T-ALL cases. A virtually identical pattern of MTS2/p15 deletion was detected in these patients: p15 was deleted in 37 of 38 cases with p16 deletion, and p15 was not deleted in any p16-positive specimens. P16/p15 deletions were significantly related to poor prognosis factors including age under 1 year (P < 0.001), initial white cell counts greater than 50 × $10^{9}$per liter (P <. 001), and T cell phenotype P < 005). Analysis of all 105 patients revealed that the 5-year disease-free survival rate was 68 % for patients without p 16/p15 deletions and 35 % for those with p16/p15 deletions (P <. 005). The association between gene deletion at initial diagnosis and unfavorable outcome suggests that loss of these genes is clinically significant and indicates a need for prospective studies of p16/p15 deletion in pediatric ALL patients. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/08880019709030900 |
| Ending Page | 150 |
| Page Count | 10 |
| Starting Page | 141 |
| ISSN | 08880018 |
| e-ISSN | 15210669 |
| DOI | 10.3109/08880019709030900 |
| Journal | Pediatric hematology and oncology |
| Issue Number | 2 |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1997-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Pediatric hematology and oncology Pediatric Acute Lymphoblastic Leukemia P16/p15 Gene Deletion |
| Content Type | Text |
| Subject | Hematology Pediatrics, Perinatology and Child Health Oncology |
