Loading...
Please wait, while we are loading the content...
Similar Documents
Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia
| Content Provider | Scilit |
|---|---|
| Author | Hatta, Y. Hirama, T. Miller, Cw Yamada, Y. Tomonaga, M. Koeffler, Hp |
| Copyright Year | 1995 |
| Description | Adult T-cell leukemia (ATL) is associated with prior infection with human T-cell leukemia virus type I (HTLV-I). Twenty to 40 years often elapse from viral infection to overt ATL, suggesting that other genetic events must occur to produce frank leukemia. The p15 (MTS2) and p16 (CDKN2/MTS1) genes located on chromosome 9p have been implicated as candidate tumor-suppressor genes in several types of tumors. We examined for alterations of these genes in ATL using Southern blot and polymerase chain reaction-single-strand conformation polymorphism analyses. Both p15 and p16 genes were homozygously deleted in 4 of 23 acute/lymphomatous ATL (17%). An additional 3 (13%) and 4 (17%) acute/lymphomatous samples had hemizygous deletions in at least one exon of p15 and p16, respectively. One of 14 chronic ATL samples had a homozygously deleted p16 gene and another had a hemizygous deletion of p16. Neither homozygous nor hemizygous deletions of the p15 gene were found in chronic ATL. In total, 10 of 37 (27%) ATL samples had loss of the p15 and/or p16 genes. No point mutations of the p15 and p16 genes were found. The ATL patient with a homozygously deleted p16 in the chronic phase rapidly progressed to acute ATL and died within 6 months of the initial diagnosis. One instructive patient had no detectable deletion of the p15 and p16 genes during the chronic phase of ATL but had a homozygous deletions of both genes when she progressed to acute ATL. Our results suggest an association of p15/p16 deletions with development of acute ATL. |
| Related Links | https://ashpublications.org/blood/article-pdf/85/10/2699/614191/2699.pdf |
| Ending Page | 2704 |
| Page Count | 6 |
| Starting Page | 2699 |
| DOI | 10.1182/blood.v85.10.2699.bloodjournal85102699 |
| Journal | Blood |
| Issue Number | 10 |
| Volume Number | 85 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1995-05-15 |
| Access Restriction | Open |
| Subject Keyword | Virology Conformation Virus P16 Adult Leukemia Deletions Atl P15 Hemizygous Homozygously Journal: Blood (Vol- 112, Issue- 10) |
| Content Type | Text |
| Resource Type | Article |
