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Enhancing the Drug Discovery Process by Integration of Structure-Based Drug Design and Combinatorial Synthesis
| Content Provider | Scilit |
|---|---|
| Copyright Year | 2001 |
| Description | In the last decade, drug discovery has changed radically. This change has been driven by technological advances in biological science, rapid follow-up activities in chemistry, and powerful computer techniques. Of these, structure-based drug design (SBDD) and combinatorial chemistry (CC) have proved to be successful methodologies. Knowledge of the three-dimensional (3D) structure of a biological target can help to identify a lead compound and subsequently guide its optimization. Combinatorial chemistry, on the other hand, is a synthetic strategy whereby molecular diversity can be rapidly reproduced in the laboratory with the specific aim of targeting a biological system. Book Name: Combinatorial Library Design and Evaluation |
| Related Links | https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9781482270761-25&type=chapterpdf |
| Ending Page | 624 |
| Page Count | 42 |
| Starting Page | 583 |
| DOI | 10.1201/9781482270761-25 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2001-06-26 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Combinatorial Library Design and Evaluation Medicinal Chemistry Structure Optimization Combinatorial Diversity Rapidly Technological Radically |
| Content Type | Text |
| Resource Type | Chapter |
