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Salivary Glycoproteins
| Content Provider | Scilit |
|---|---|
| Author | Cohen, Robert E. Levine, Michael J. |
| Copyright Year | 2021 |
| Description | Book Name: Human Saliva: Clinical Chemistry and Microbiology |
| Abstract | 102Saliva is a complex fluid composed of a wide variety of organic and inorganic constituents which collectively act to modulate the oral environment. The protective qualities of saliva become clinically evident when salivary flow is absent or markedly decreased. Such situations, clinically termed “xerostomia” or “dry mouth”, may result from numerous factors, including removal of salivary glands following neck dissection for cancer therapy, specific disease, irradiation, and/or pharmacological agents. Nonspecific causes of xerostomia can include mouth breathing, nasal obstruction, and psychiatric distress.$ ^{1}$ -$ ^{5}$ Chronic xerostomia can lead to dry, red, sticky, and rough mucosal surfaces which bleed more easily and are increasingly susceptible to infection. The tongue becomes smooth, slimy, hypersensitive to irritation and loses taste acuity.$ ^{6}$ -$ ^{8}$ The accumulation of bacterial plaque and debris can lead to an increased incidence of dental caries and periodontal disease.$ ^{3} ^{,} ^{9}$ In addition, facility of speech and management of the edentulous patient become more difficult. Studies over the past two decades have suggested that many of the protective effects of saliva can be attributed to particular salivary glycoproteins, such as mucins, proline-rich glycoproteins, α-amylases, lactoferrin, salivary peroxidase, and secretory IgA. We are just beginning, however, to elucidate the precise structure, function, and salivary concentrations of these molecules. This information will be required in order for the dental scientist to develop sialochemical tests and artificial salivas which can be used by the clinician to monitor, regulate, and/or augment the healthy or diseased oral environment. This chapter summarizes current information on various aspects of the major salivary glycoproteins, including structure, synthetic pathways involved in construction and processing, function, their structural modulation, and future studies and clinical applications. |
| Related Links | https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9781003210399-4&type=chapterpdf |
| Ending Page | 130 |
| Page Count | 30 |
| Starting Page | 101 |
| DOI | 10.1201/9781003210399-4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2021-05-19 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Human Saliva: Clinical Chemistry and Microbiology Dentistry and Oral Surgery Glycoproteins Structure Salivary Xerostomia Oral Environment Dental Function |
| Content Type | Text |
| Resource Type | Chapter |
