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Hsa_circ_0003645 Promotes Breast Cancer Progression by Regulating miR-139-3p/HMGB1 Axis
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Jinjun Ke, Shun Zheng, Weihong Zhu, Zhi Wu, Yanle |
| Copyright Year | 2020 |
| Description | Background: The aim of the present study was to investigate the effect of over-expressing circular RNA (circ_0003645) on cell functions and its molecular mechanism in breast cancer. Methods: The expression profile of circ_0003645, breast cancer cell lines, and the transcription levels of circular RNA, miRNA and HMGB1 gene were detected by qRT-PCR. Flow cytometry analysis was manipulated to evaluate cancer cell proliferation and cell apoptosis. The correlation between miR-139p-3p and circular_0003645 or HMGB1 was predicted by GEO, and TCGA was confirmed using the dual-luciferase reporter assay. Results: Circ_0003645 expression was conspicuously increased in both the breast cancer tissues and cell lines. Circ_0003645 knockdown inhibited cell proliferation and induced the apoptosis of breast cancer cells in vitro and in vivo. By sponging miR-139-3p, circ_0003645 promoted the breast cancer cells progression and positively regulated HMGB1 gene. Conclusion: Circ_0003645 functions as a ceRNA for miR-139-3p, which could upregulate HMGB1 and further promote cell proliferation in breast cancer. |
| Related Links | https://www.dovepress.com/getfile.php?fileID=62478 |
| Ending Page | 10372 |
| Page Count | 12 |
| Starting Page | 10361 |
| ISSN | 11786930 |
| DOI | 10.2147/ott.s265796 |
| Journal | OncoTargets and therapy |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-10-01 |
| Access Restriction | Open |
| Subject Keyword | Oncology Cancer Pathogenesis Target Circular Rna Knockdown Proliferation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
