NDLI: Next-generation sequencing in precision oncology: challenges and opportunities

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Next-generation sequencing in precision oncology: challenges and opportunities

Content Provider	Scilit
Author	Kruglyak, Kristina M. Lin, Erick Ong, Frank S.
Copyright Year	2014
Description	High throughput gene sequencing is transforming the utilization of genomics in patient care by providing physicians with a powerful tool to aid the diagnosis and management of disease, particularly in precision oncology. As next-generation sequencing (NGS)-based diagnostic assays are developed, significant hurdles such as assessing tumor heterogeneity, characterizing 'driver' and 'passenger' mutations, typing molecular signatures of individual cancers and determining limits of detection pose significant challenges for clinical laboratories and downstream bioinformatics analyses. Despite these challenges, NGS has the potential to affect all facets of cancer treatment, including early detection and diagnosis through cancer screening in at-risk populations and assessing therapeutic efficacy by detection of circulating tumor DNA via noninvasive blood draws. As the utilization of NGS in precision oncology matures, NGS-based laboratory tests could be used throughout the evolution of cancer in patients and allow for cancers to be monitored and managed as a chronic disease, rather than an acute condition.
Related Links	http://www.tandfonline.com/doi/pdf/10.1586/14737159.2014.916213?needAccess=true
Ending Page	637
Page Count	3
Starting Page	635
ISSN	14737159
e-ISSN	17448352
DOI	10.1586/14737159.2014.916213
Journal	Expert Review of Molecular Diagnostics
Issue Number	6
Volume Number	14
Language	English
Publisher	Informa UK Limited
Publisher Date	2014-05-03
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Bioinformatics Next-generation Sequencing Personalized Medicine Precision Oncology Tumor Heterogeneity
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Molecular Medicine Pathology and Forensic Medicine

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