NDLI: Potential clinical utility of ultrasensitive circulating tumor DNA detection with CAPP-Seq

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Potential clinical utility of ultrasensitive circulating tumor DNA detection with CAPP-Seq

Content Provider	Scilit
Author	Bratman, Scott Newman, Aaron Alizadeh, Arash Ash Diehn, Maximilian
Copyright Year	2015
Description	Tumors continually shed DNA into the circulation, where it can be noninvasively accessed. The ability to accurately detect circulating tumor DNA (ctDNA) could significantly impact the management of patients with nearly every cancer type. Quantitation of ctDNA could allow objective response assessment, detection of minimal residual disease and noninvasive tumor genotyping. The latter application overcomes the barriers currently limiting repeated tumor tissue sampling during therapy. Recent technical advancements have improved upon the sensitivity, specificity and feasibility of ctDNA detection and promise to enable innovative clinical applications. Here, we focus on the potential clinical utility of ctDNA analysis using CAncer Personalized Profiling by deep Sequencing (CAPP-Seq), a novel next-generation sequencing-based approach for ultrasensitive ctDNA detection. Applications of CAPP-Seq for the personalization of cancer detection and therapy are discussed.
Related Links	https://www.tandfonline.com/doi/pdf/10.1586/14737159.2015.1019476?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052032/pdf
Ending Page	719
Page Count	5
Starting Page	715
ISSN	14737159
e-ISSN	17448352
DOI	10.1586/14737159.2015.1019476
Journal	Expert Review of Molecular Diagnostics
Issue Number	6
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	2015-06-03
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Biomarker Circulating Tumor Dna Next-generation Sequencing Noninvasive Ultrasensitive Next Generation Sequencing
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Molecular Medicine Pathology and Forensic Medicine

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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