NDLI: Posterior juxtascleral delivery of anecortave acetate for treatment of age-related macular degeneration

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Posterior juxtascleral delivery of anecortave acetate for treatment of age-related macular degeneration

Content Provider	Scilit
Author	Slakter, Jason Dahlin, David
Copyright Year	2019
Description	Exudative age-related macular degeneration (ARMD) is the most common untreatable cause of functional blindness in patients over the age of 50 years. In exudative ARMD, vision loss is the direct result of abnormal vessel growth through Bruch's membrane, with associated leakage and hemorrhage. A number of pharmacologic agents designed to inhibit blood vessel growth are currently being evaluated for the treatment of exudative ARMD. Clinical evidence of exudative ARMD places a patient at greatly increased risk for serious vision loss regardless of the location of the classic choroidal neovascularization (CNV) or its angiographic characteristics. Effective transscleral delivery of anecortave acetate has required the development of a posterior juxtascleral cannula designed to follow the curve of the outer scleral surface along the tissue plane between sclera and Tenon's capsule. Anecortave acetate has been shown to inhibit angio-genesis in multiple preclinical models, and is superior to vehicle administration for inhibiting the growth of established CNV lesions. Book Name: Vitreoretinal Surgical Techniques
Related Links	https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9780203734315-64&type=chapterpdf
Ending Page	651
Page Count	10
Starting Page	642
DOI	10.1201/9780203734315-64
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-07-12
Access Restriction	Open
Subject Keyword	Book Name: Vitreoretinal Surgical Techniques Oceanography Treatment Exudative Posterior Juxtascleral Delivery of Anecortave Acetate Degeneration Vessel
Content Type	Text
Resource Type	Chapter

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