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Serum levels of malondialdehyde, vitamin C and E in idiopathic nephrotic syndrome: a meta-analysis
| Content Provider | Scilit |
|---|---|
| Author | Mao, Song Zhang, Aihua Huang, Songming |
| Copyright Year | 2014 |
| Description | It is well documented that oxidative stress is involved in the pathogenesis of idiopathic nephrotic syndrome (INS). Malondialdehyde (MDA) is a measurement of lipid oxidation; vitamin C and E are important components of antioxidants. However, the association between MDA, vitamin C or E levels and INS remains elusive. A meta-analysis was performed to investigate the alteration of serum levels of MDA, vitamin C and E in INS compared with controls. Eight studies were included in our meta-analysis according to predefined criteria. Active INS patients demonstrated significantly higher level of serum MDA (SMD: 2.13, 95% CI: 1.511 to 2.749, p < 10(-4)), markedly lower levels of serum vitamin C (SMD: -1.449, 95% CI: -2.616 to -0.281, p = 0.015) and E (SMD: -1.45, 95% CI: -2.544 to -0.356, p = 0.009) compared with those in controls. Active steroid-sensitive nephrotic syndrome (SSNS) patients showed comparable levels of serum vitamin C and E to those in controls. INS subjects in the remission stage demonstrated significantly higher level of serum MDA (SMD: 1.028, 95% CI: 0.438 to 1.617, p < 10(-4)), markedly lower level of serum vitamin C (SMD: -2.235, 95% CI: -3.048 to -1.421, p < 10(4)) and similar level of serum vitamin E compared with those in controls. No significant publication bias was observed. In conclusion, the disorder of MDA and vitamin C persists in the remission stage of INS. It seems that the serum levels of vitamin C and E is associated with the responsiveness of INS to steroids. However, more studies should be performed in the future. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/0886022X.2014.900430?needAccess=true |
| Ending Page | 999 |
| Page Count | 6 |
| Starting Page | 994 |
| ISSN | 0886022X |
| e-ISSN | 15256049 |
| DOI | 10.3109/0886022x.2014.900430 |
| Journal | Renal Failure |
| Issue Number | 6 |
| Volume Number | 36 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-03-26 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Antioxidant Idiopathic Nephrotic Syndrome Meta-analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine Nephrology |
