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Bone Marrow and Hematological Toxicity
| Content Provider | Scilit |
|---|---|
| Author | Heide, Elena S. Mell, Loren K. |
| Copyright Year | 2019 |
| Description | The human bone and bone marrow (BM) constitute one of the body's largest and most important organ systems. Altogether, the bones (~15%), BM (~4%), and blood (~7%) account for approximately 25% of the entire human body weight (Paul 2013). The BM system is highly susceptible to harmful outside exposure, and is an important dose-limiting organ during cancer therapy, particularly radiation therapy (RT) and chemotherapy. Radiation is one of the most widely known and well-studied toxins impacting BM function. Physicians routinely obtain blood counts for diagnosing hematological disorders and when monitoring for toxicity. Recently, increased efforts have been focused on techniques to circumvent hematopoietic toxicities. This chapter will discuss the historical study of hematopoiesis and BM injury, the anatomic physiology of bone and the BM microenvironment, pathologic changes and clinical symptoms that occur when BM is exposed to differing doses of radiation, how BM damage is assessed, and modern clinical applications to both induce and mitigate BM injury. Book Name: Modelling Radiotherapy Side Effects |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2016-0-29219-6&isbn=9781315270814&doi=10.1201/b21956-13&format=pdf |
| Ending Page | 335 |
| Page Count | 27 |
| Starting Page | 309 |
| DOI | 10.1201/b21956-13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-06-11 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Modelling Radiotherapy Side Effects Biomedical Engineering Physiology Toxicity Hematopoietic Function Bone Marrow Hematological Historical Study Bm Injury |
| Content Type | Text |
| Resource Type | Chapter |
