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Clarithromycin-Susceptible But Virulent Helicobacter pylori Strains Infecting Iranian Patients’ Stomachs
| Content Provider | Scilit |
|---|---|
| Author | Khani, Shadiyeh Abadi, Amin Talebi Bezmin Mobarez, Ashraf Mohabati |
| Copyright Year | 2019 |
| Description | Introduction: Helicobacter pylori was discovered first in the stomachs of patients with gastritis and ulcers by Marshall and Warren in 1982. This discovery majorly affected many research areas of gastroenterology. Since then, the main aim has been to eradicate this microaerophilic bacterium from the stomachs of infected subjects. Methods: We studied symptomatic cases by endoscopic surgery and examined the prevalence of cagA–vacA genotypes among the H. pylori isolates. H. pylori isolated from antral biopsies of patients with gastritis and duodenal ulcer were subjected to antimicrobial susceptibility testing and PCR genotyping by using routine bacterial cultures. Clarithromycin-susceptibility profiling was done by the E-test. DNA was extracted using standard manufacturer protocols with minor modifications and cagA and vacA genotyping was done PCR. Results: In our study, all strains identified as H. pylori in culture (61/81) were confirmed by PCR by amplifying a fragment of the glmM gene. Totally, 61 patients were confirmed to be positive for H. pylori and they were included in the genotyping and antibiotic-susceptibility testing. Thirteen H. pylori strains were determined to be resistant to clarithromycin. Discussion: Current accumulating data indicate that both clarithromycin-resistant and susceptible isolates of H. pylori need to be screened and tracked in populations. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830365/pdf https://www.dovepress.com/getfile.php?fileID=53666 |
| Ending Page | 3420 |
| Page Count | 6 |
| Starting Page | 3415 |
| ISSN | 11786973 |
| e-ISSN | 11786973 |
| DOI | 10.2147/idr.s223602 |
| Journal | Infection and Drug Resistance |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-11-01 |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Antibiotic Susceptibility Clarithromycin E-test Helicobacter Pylori Genotypes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pharmacology Pharmacology (medical) |
