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Increase in antibiotic resistant Helicobacter pylori in a University Hospital in Japan
| Content Provider | Scilit |
|---|---|
| Author | Kageyama, Chihiro Sato, Mayu Sakae, Hiroyuki Obayashi, Yuka Kawahara, Yoshiro Mima, Takehiko Matsushita, Osamu Yokota, Kenji Mizuno, Motowo Okada, Hiroyuki |
| Copyright Year | 2019 |
| Description | Journal: Infection and Drug Resistance Background: Eradication effectively prevents Helicobacter pylori-associated diseases; however, H. pylori antibiotic resistance has increased throughout Japan and worldwide. This study aimed to assess rates of resistance to antibiotics; amoxicillin, clarithromycin and metronidazole in a University Hospital in Japan. Materials and methods: H. pylori (208 strains) were isolated from patients at the Okayama University Hospital in Japan. The minimum inhibitory concentrations (MIC) were determined using the mean values of the E-test to determine the antimicrobial susceptibilities of the strains. Sequencing and gene analysis were performed to analyze resistance genes to clarithromycin and amoxicillin. Results: Rates of amoxicillin, clarithromycin, and metronidazole resistance were 13%, 48%, and 49%, respectively. Genetic analysis indicated that the A2143G point mutation in 23S rDNA is closely associated with the MIC of clarithromycin. The MIC in amoxicillin-resistant strains increased with an increase in the number of PBP1A amino acids mutations. Conclusion: Genetic analysis for resistant strains is not clinically effective in cases of amoxicillin resistance. Numerous bacteria with already high antibiotic resistance rates have been isolated in large hospitals such as a University Hospital. For effective eradication therapy, MIC measurement should be considered via several methods. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419596/pdf https://www.dovepress.com/getfile.php?fileID=48528 |
| Ending Page | 602 |
| Page Count | 6 |
| Starting Page | 597 |
| ISSN | 11786973 |
| e-ISSN | 11786973 |
| DOI | 10.2147/idr.s196452 |
| Journal | Infection and Drug Resistance |
| Volume Number | ume 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Infection and Drug Resistance Integrative and Complementary Medicine Helicobacter Pylori Clarithromycin University Hospital |
| Content Type | Text |
| Subject | Infectious Diseases Pharmacology Pharmacology (medical) |
