Loading...
Please wait, while we are loading the content...
Relationship Between Interleukin-6 −174G/C Genetic Variant and Efficacy of Methotrexate Treatment in Psoriatic Arthritis Patients
| Content Provider | Scilit |
|---|---|
| Author | Sokolik, Renata Iwaszko, Milena Świerkot, Jerzy Wysoczańska, Barbara Korman, Lucyna Wiland, Piotr Bogunia-Kubik, Katarzyna |
| Copyright Year | 2021 |
| Description | Introduction: The purpose of the study was to investigate whether single-nucleotide polymorphisms (SNPs) IL-6 − 174 G/C and IL-6R Asp358Ala are associated with susceptibility to psoriatic arthritis (PsA) or affect response to treatment with methotrexate (MTX). Patients and Methods: Seventy-four patients diagnosed with PsA and qualified for MTX treatment were enrolled to the study. The control group consisted of 120 healthy individuals. Polymorphisms IL-6 − 174 G/C and IL-6R Asp358Ala were genotyped using a polymerase chain reaction (PCR) amplification employing LightSNiP assays. Results: A significant association between the IL-6 − 174 CC genotype and an improved clinical outcome of MTX therapy was observed. A good response was more frequently observed among PsA patients bearing the IL-6 − 174 CC genotype than patients with the GC or GG genotypes (P = 0.007). On the other hand, patients carrying the IL-6 − 174 GC genotype less frequently responded to MTX treatment as compared to patients with other genotypes (P = 0.006). With respect to the IL-6R Asp358Ala SNP, there were no significant differences in genotype and allelic frequencies in relation to clinical outcome of MTX treatment. No association was found between the IL-6 − 174 G/C or IL-6R Asp358Ala SNPs and PsA susceptibility. Conclusion: Results from this study provide evidence that the IL-6 − 174 G/C polymorphism might influence efficacy of MTX treatment. |
| Related Links | https://www.dovepress.com/getfile.php?fileID=66072 |
| Ending Page | 166 |
| Page Count | 10 |
| Starting Page | 157 |
| ISSN | 11787066 |
| e-ISSN | 11787066 |
| DOI | 10.2147/pgpm.s264555 |
| Journal | Pharmacogenomics and Personalized Medicine |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2021-01-01 |
| Access Restriction | Open |
| Subject Keyword | Rheumatology Psoriatic Arthritis Methotrexate Treatment Il-6 −174g/c Polymorphism Il-6r Asp358ala Polymorphism |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Molecular Medicine |
