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Study on the possible role of the -174G>C IL-6 promoter polymorphism in predicting response to rituximab in rheumatoid arthritis
| Content Provider | Open Access Library (OALib) |
|---|---|
| Author | M. Fabris L. Quartuccio S. Lombardi M. Benucci |
| Abstract | Several studies demonstrated the efficacy of the B-cell depletion therapy with rituximab (RTX) in RA patients, including those unresponsive to anti- TNF therapy, underlying the important role of B cells in this disease (1-5). Several recent papers have demonstrated a differential effects of RTX in depleting B-cells and blocking plasma cell generation at the synovial and at the bone marrow level (7-9). This differential effect may explain why among patients who respond to RTX, some relapse while others show a very prolonged response, independently from the reappearance of B-cells in the peripheral blood (6). However, the efficacy of RTX may also depend on the individual genetic predisposition. At this regard, very few data were produced by now. |
| ISSN | 00487449 |
| Journal | Reumatismo |
| DOI | 10.4081/reumatismo.2010.253 |
| Publisher | PAGEPress Publications |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Rheumatology |
