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VEGF and Notch Signaling
| Content Provider | Scilit |
|---|---|
| Author | Hellström, Mats Phng, Li-Kun Gerhardt, Holger |
| Copyright Year | 2007 |
| Description | Tubular sprouting in angiogenesis relies on division of labour between endothelial tip cells, leading and guiding the sprout, and their neighboring stalk cells, which divide and form the vascular lumen. We previously learned how the graded extracellular distribution of heparin-binding vascular endothelial growth factor (VEGF)-A orchestrates and balances tip and stalk cell behavior. Recent data now provided insight into the regulation of tip cell numbers, illustrating how delta-like (DII)4-Notch signalling functions to limit the explorative tip cell behavior induced by VEGF-A. These data also provided a first answer to the question why not all endothelial cells stimulated by VEGF-A turn into tip cells. Here we review this new model and discuss how VEGF-A and DII4/Notch signalling may interact dynamically at the cellular level to control vascular patterning. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cam.1.3.4978?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634014/pdf |
| Ending Page | 136 |
| Page Count | 4 |
| Starting Page | 133 |
| ISSN | 19336918 |
| e-ISSN | 19336926 |
| DOI | 10.4161/cam.1.3.4978 |
| Journal | Cell adhesion & migration |
| Issue Number | 3 |
| Volume Number | 1 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2007-07-01 |
| Access Restriction | Open |
| Subject Keyword | Developmental Biology Angiogenesis Mouse Development Vegf-a Tip Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cellular and Molecular Neuroscience |
