NDLI: Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues

Content Provider	Springer Nature Link
Author	Chauvet, Sophie Burk, Katja Mann, Fanny
Copyright Year	2013
Abstract	Many organs, such as lungs, nerves, blood and lymphatic vessels, consist of complex networks that carry flows of information, gases, and nutrients within the body. The morphogenetic patterning that generates these organs involves the coordinated action of developmental signaling cues that guide migration of specialized cells. Precision guidance of endothelial tip cells by vascular endothelial growth factors (VEGFs) is well established, and several families of neural guidance molecules have been identified to exert guidance function in both the nervous and the vascular systems. This review discusses recent advances in VEGF research, focusing on the emerging role of neural guidance molecules as key regulators of VEGF function during vascular development and on the novel role of VEGFs in neural cell migration and nerve wiring.
Starting Page	1685
Ending Page	1703
Page Count	19
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	70
Issue Number	10
e-ISSN	14209071
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2013-03-12
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Axon guidance Angiogenesis VEGF Tip cell Growth cone Cell Biology Biomedicine general Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues