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Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen
| Content Provider | Scilit |
|---|---|
| Author | Mansour, Diana Verhoeven, Carole Sommer, Werner Weisberg, Edith Taneepanichskul, Surasak Melis, Gian Benedetto Sundström-Poromaa, Inger Korver, Tjeerd |
| Copyright Year | 2011 |
| Description | Objectives: The primary objective was to assess the efficacy, cycle control and tolerability of a monophasic combined oral contraceptive (COC) containing nomegestrol acetate (NOMAC) and 17β-oestradiol (E2). Effects on acne were evaluated as a secondary objective. Results: were compared to those of a COC containing drospirenone (DRSP) and ethinylestradiol (EE). Methods Women (aged 1850 years) were randomised to receive NOMAC/E2 (2.5 mg/1.5 mg) in a 24/4-day regimen (n = 1591) or DRSP/EE (3 mg/30 μg) in a 21/7-day regimen (n = 535) for 13 cycles. Results: Estimated Pearl Indices for NOMAC/E2 and DRSP/EE were 0.38 and 0.81 in women aged ≤ 35 years and 0.31 and 0.66 for all women (18-50 years), respectively. Scheduled withdrawal bleedings were shorter and lighter among users of NOMAC/E2 and were sometimes absent altogether. Intracyclic bleeding/spotting was infrequent in both groups, and decreased over time. Type and frequency of adverse events were similar to those typically reported for COCs. Conclusions: These data show that NOMAC/E2 provides high contraceptive efficacy with acceptable cycle control as well as an overall adverse event profile similar to that of DRSP/EE |
| Related Links | http://europepmc.org/articles/pmc3233274?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233274/pdf |
| Ending Page | 443 |
| Page Count | 14 |
| Starting Page | 430 |
| ISSN | 13625187 |
| e-ISSN | 14730782 |
| DOI | 10.3109/13625187.2011.614029 |
| Journal | The European Journal of Contraception & Reproductive Health Care |
| Issue Number | 6 |
| Volume Number | 16 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-10-13 |
| Access Restriction | Open |
| Subject Keyword | Combined Oral Contraceptive Nomegestrol Acetate 17β-oestradiol Efficacy Safety Cycle Control |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Reproductive Medicine Obstetrics and Gynecology |
