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Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function
| Content Provider | Scilit |
|---|---|
| Author | Ågren, Ulla M. Anttilat, Marjatta Mäenpää-Liukko, Kristiina Rantala, Maija-Liisa Rautiainen, Hilkka Sommer, Werner F. Mommers, Ellen |
| Copyright Year | 2011 |
| Description | To compare the effects of two monophasic combined oral contraceptives, containing either nomegestrol acetate/17β-oestradiol (NOMAC/E2) or levonorgestrel/ ethinylestradiol (LNG/EE) on endocrine function, androgens, and sex hormone-binding globulin (SHBG). Randomised, open-label, multi-centre trial involving 121 healthy women, aged 18-50 years old. Participants received NOMAC/E2 (2.5 mg/1.5 mg) in a 24/4-day regimen (n=60) or LNG/EE (150 μg/30 μg) in a 21/7-day regimen (n=61) for six cycles. The primary outcome was the change from baseline to cycle 6 in markers of adrenal and thyroid function, androgens, and SHBG. Total cortisol, corticosteroid-binding globulin (CBG), and thyroxine-binding globulin (TBG) increased from baseline in both groups, with significantly greater increases in the LNG/EE group. No relevant changes from baseline or differences between the groups were observed for thyroid-stimulating hormone (TSH) and free thyroxine (T4). Androgens and androgen precursors decreased from baseline in both groups, with significantly greater decreases in the LNG/EE group (except for free testosterone). A greater increase in SHBG was observed with NOMAC/E2 than with LNG/EE. NOMAC/E2 has significantly less influence on markers of adrenal and thyroid function and androgens than LNG/EE. The clinical relevance of these findings requires further study. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233273/pdf |
| Ending Page | 467 |
| Page Count | 10 |
| Starting Page | 458 |
| ISSN | 13625187 |
| e-ISSN | 14730782 |
| DOI | 10.3109/13625187.2011.614363 |
| Journal | The European Journal of Contraception & Reproductive Health Care |
| Issue Number | 6 |
| Volume Number | 16 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-09-26 |
| Access Restriction | Open |
| Subject Keyword | Endocrinology and Metabolism Oral Contraceptives Nomegestrol Acetate 17β-oestradiol Adrenal Thyroid Androgen |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Reproductive Medicine Obstetrics and Gynecology |
