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Cumulative use of salivary markers with an adaptive design improves detection of periodontal disease over fixed biomarker thresholds
| Content Provider | Scilit |
|---|---|
| Author | Gürsoy, Ulvi Kahraman Pussinen, Pirkko J. Salomaa, Veikko Syrjäläinen, Sanna Könönen, Eija |
| Copyright Year | 2018 |
| Description | Objective: Aim was to analyze the diagnostic ability of cumulative risk score (CRS), which uses salivary levels of Porphyromonas gingivalis, interleukin (IL)-1β, and matrix metalloproteinase (MMP)-8 in an adaptive design, compared to previously reported thresholds of each marker alone. Materials and Methods: Oral and general health information of 463 participants were included in the analysis. Having the percentage of bleeding on probing (BOP) > 25%, having at least two sites with probing pocket depth (PPD) of 4–5 mm or having at least one tooth with alveolar bone loss (ABL) of at least 1/3 of the root length were accepted as outcome variables. Being above the salivary threshold concentrations of P. gingivalis, IL-1β, and MMP-8 and CRS values were used as explanatory variables. Receiver operating characteristics (ROC) producing an area under the curve (AUC) and multinomial regression analysis were used in statistical analysis. Results: CRS provided AUCs larger than any other tested biomarker threshold. Sensitivity and specificity of CRS for detecting clinical markers of periodontitis were acceptable, and a strong association was observed between the highest CRS score and having at least two sites with PPD of 4–5 mm. Conclusion: CRS brings additional power over fixed thresholds of single biomarkers in detecting periodontitis. |
| Related Links | https://helda.helsinki.fi/bitstream/10138/305973/1/Cumulative_use_of_salivary_markers.pdf |
| Ending Page | 496 |
| Page Count | 4 |
| Starting Page | 493 |
| ISSN | 00016357 |
| e-ISSN | 15023850 |
| DOI | 10.1080/00016357.2018.1441436 |
| Journal | Acta Odontologica Scandinavica |
| Issue Number | 7 |
| Volume Number | 76 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-10-03 |
| Access Restriction | Open |
| Subject Keyword | Dentistry and Oral Surgery Biomarker Interleukin-1β Matrix Metalloproteinase-8 Periodontitis Porphyromonas Gingivalis Saliva |
| Content Type | Text |
| Resource Type | Article |
| Subject | Dentistry Medicine |
