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Use of host- and bacteria-derived salivary markers in detection of periodontitis: a cumulative approach.
| Content Provider | Europe PMC |
|---|---|
| Author | Gursoy, Ulvi Kahraman Könönen, Eija Pussinen, Pirkko J. Tervahartiala, Taina Hyvärinen, Kati Suominen, Anna L. Uitto, Veli-Jukka Paju, Susanna Sorsa, Timo |
| Copyright Year | 2011 |
| Abstract | In the present study, we propose a novel diagnostic approach, using 3 different salivary markers, representing periodontal pathogen burden, inflammation, and tissue degradation, for detecting periodontitis. The salivary concentrations of Porphyromonas gingivalis, interleukin-1β, and matrix metalloproteinase-8, available from salivary specimens of 165 subjects (84 subjects with advanced periodontitis and 81 controls), were calculated together to obtain a cumulative risk score (CRS). In the calculation of CRS, the concentrations of each marker were divided into tertiles, and cumulative sub-score per each subject were calculated by the multiplication of the tertile values. Three CRS groups, indicating the lowest, medium, or highest risk, were formed with the cumulative sub-scores. Logistic regression analysis and ROC curves were performed to study the association of CRS with periodontitis. The results indicate that CRS, calculated from the 3 salivary biomarkers, is associated with advanced periodontitis more strongly than any of the markers individually. CRS offers a novel, non-invasive model for advanced periodontitis risk categorization that is especially useful in large population surveys where a periodontal examination is not feasible. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3825247&blobtype=pdf |
| ISSN | 02780240 |
| Journal | Disease markers [Dis Markers] |
| Volume Number | 30 |
| PubMed Central reference number | PMC3825247 |
| Issue Number | 6 |
| PubMed reference number | 21725158 |
| e-ISSN | 18758630 |
| DOI | 10.3233/dma-2011-0788 |
| Language | English |
| Publisher | IOS Press |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Rights License | Copyright © 2011 Hindawi Publishing Corporation. |
| Subject Keyword | IL-1β MMP-8 Porphyromonas gingivalis risk score saliva |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Genetics Clinical Biochemistry Molecular Biology |
