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Erythromycin Treatment is Beneficial for Longstanding Moraxella catarrhalis Associated Cough in Children
| Content Provider | Scilit |
|---|---|
| Author | Darelid, Johan Löfgren, Sture Malmvall, Bo-Eric |
| Copyright Year | 1993 |
| Description | The benefits of antibiotic treatment and a nasopharyngeal culture in children with longstanding cough were analysed in a prospective randomized open study. Clinically suspected pertussis was excluded. Of 40 children given erythromycin for 7 days, 35 (88%) recovered in one week, compared with 17/47 (36%) untreated (p< 0.0001). Erythromycin eliminated Moraxella catarrhalis from the nasopharynx in 21/31 children (68%), compared with spontaneous disappearance in 7/35 (20%) untreated controls (p < 0.001). Purulent bronchitis or otitis media occurred in 2 children (5%) in the treatment group and in 21 (45%) in the control group (p < 0.01). To evaluate the clinical role of isolated pathogens, the 47 untreated subjects were studied. Seven of 35 children harbouring M. catarrhalis recovered, compared with 8/12 in whom this bacterium was absent (p < 0.01). No correlation was found between the isolation of Haemophilus influenzae or Streptococcus pneumoniae and the clinical outcome. Children with persistent cough >10 days may benefit from erythromycin treatment. M. catarrhalis in the nasopharynx indicates prolonged symptoms and increased risk of bacterial complications. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/00365549309008506 |
| Ending Page | 329 |
| Page Count | 7 |
| Starting Page | 323 |
| ISSN | 00365548 |
| e-ISSN | 16511980 |
| DOI | 10.3109/00365549309008506 |
| Journal | Scandinavian journal of infectious diseases |
| Issue Number | 3 |
| Volume Number | 25 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1993-01-01 |
| Access Restriction | Open |
| Subject Keyword | Respiratory System Children Nasopharynx Moraxella Untreated Catarrhalis Longstanding Erythromycin Treatment |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Microbiology Microbiology (medical) |
