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The inhibitory effect of MSCs expressing TRAIL as a cellular delivery vehicle in combination with cisplatin on hepatocellular carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Bo Shan, Hong Li, Dan Li, Zheng-Ran Zhu, Kang-Shun Jiang, Zaibo |
| Copyright Year | 2012 |
| Description | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been demonstrated to induce cell apoptosis in many types of tumors, while many hepatocellular carcinoma (HCC) cells display high resistance to TRAIL. Another outstanding limitation of TRAIL is the short half-life in vivo. Stem cell-based therapies provide a promising approach for the treatment of many types of tumors because of the ability of tropism. Therefore, as a new therapeutic strategy, the combination of chemotherapeutic agents and TRAIL gene modified MSCs (TRAIL-MSCs) would improve the therapeutic efficacy of HCC in vivo. This is the first time to show the potential of combination of chemotherapeutic agents and MSCs as a gene vector in the therapy of HCC. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cbt.21347?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469475/pdf https://www.landesbioscience.com/journals/cbt/BZhangCBT13-12.pdf |
| Ending Page | 1184 |
| Page Count | 10 |
| Starting Page | 1175 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.4161/cbt.21347 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 12 |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2012-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Biology & Therapy Biochemistry and Molecular Biology Trail Bioluminescence Imaging Cisplatin Hepatocellular Carcinoma Lentiviral Mesenchymal Stem Cells Synergistic Effect |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
