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Correlation of factor XIIIa + dermal dendrocytes with paracoccidioidomycosis skin lesions
| Content Provider | Scilit |
|---|---|
| Author | Pagliari, C. Sotto, M. N. |
| Copyright Year | 2002 |
| Description | We demonstrated and quantified by immunohistochemistry the factor XIIIa+ dermal dendrocytes (FXIIIa+ DD) in paracoccidioidomycosis skin lesions. Sixtyone biopsies were classified according to the tissue response in well-organized granulomas (group 1), poorly organized granulomas (group 2) and samples showing both kinds of granuloma (group 3). Ten biopsies from normal skin were used as controls. In order to verify the internalization of Paracoccidioides brasiliensis antigens by FXIIIa+ DD, we performed a double immunostaining technique. FXIIIa+ DD were hypertrophied with prominent dendrites and their number in the test groups was higher than in the control group, especially in the dermal papillae. P. brasiliensis yeasts were seen within the cytoplasm of FXIIIa+ DD in 40% of the immunostained biopsies. We could correlate these findings with the probable role of FXIIIa+ DD as antigen-presenting cells in the pathogenesis of skin lesions in paracoccidioidomycosis. |
| Related Links | https://academic.oup.com/mmy/article-pdf/40/4/407/2895532/40-4-407.pdf |
| Ending Page | 410 |
| Page Count | 4 |
| Starting Page | 407 |
| ISSN | 13693786 |
| DOI | 10.1080/714031129 |
| Journal | Medical mycology |
| Issue Number | 4 |
| Volume Number | 40 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2002-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Medical Mycology Mycology Biopsy Factor Xiiia Granuloma Paracoccidioidomycosis Skin Lesion Immunohistochemistry Paracoccidioides Brasiliensis Verification Yeasts Hypertrophy Skin Antigen-presenting Cells Antigens Cytoplasm Dendrites |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Veterinary |
