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Life without geminin
| Content Provider | Scilit |
|---|---|
| Author | Karamitros, Dimitris Kotantaki, Panorea Lygerou, Zoi Veiga-Fernandes, Henrique Pachnis, Vassilis Kioussis, Dimitris Taraviras, Stavros |
| Copyright Year | 2010 |
| Description | The interplay of proliferation and differentiation is essential for normal development and organogenesis. Geminin is a cell cycle regulator which controls licensing of origins for DNA replication, safeguarding genomic stability. Geminin has also been shown to regulate cellular decisions of self-renewal versus commitment of neuronal progenitor cells. We discuss here our recent analysis of mice with conditional inactivation of the Geminin gene in the immune system. Our data indicate that Geminin is not indispensable for every cell division: in the absence of Geminin, development of progenitor T cells appears largely unaffected. In contrast, rapid cell divisions, taking place in vitro upon TCR receptor activation or in vivo during homeostatic proliferation, are defective. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cc.9.16.12554?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041160/pdf |
| Ending Page | 3205 |
| Page Count | 5 |
| Starting Page | 3201 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.9.16.12554 |
| Journal | Cell Cycle |
| Issue Number | 16 |
| Volume Number | 9 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-08-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Developmental Biology Geminin Cdt1 Stem Cells Licensing Self-renewal Differentiation Cell Cycle Duration |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
