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Transcription factors and neural stem cell self-renewal, growth and differentiation
| Content Provider | Scilit |
|---|---|
| Author | Ahmed, Sohail Gan, Hui Theng Lam, Chen Sok Poonepalli, Anuradha Ramasamy, Srinivas Tay, Yvonne Tham, Muly Yu, Yuan Hong |
| Copyright Year | 2009 |
| Description | The central nervous system (CNS) is a large network of interconnecting and intercommunicating cells that form functional circuits. Disease and injury of the CNS are prominent features of the healthcare landscape. There is an urgent unmet need to generate therapeutic solutions for CNS disease/injury. To increase our understanding of the CNS we need to generate cellular models that are experimentally tractable. Neural stem cells (NSCs), cells that generate the CNS during embryonic development, have been identified and propagated in vitro. To develop NSCs as a cellular model for the CNS we need to understand more about their genetics and cell biology. In particular, we need to define the mechanisms of self-renewal, proliferation and differentiation—i.e. NSC behavior. The analysis of pluripotency of embryonic stem cells through mapping regulatory networks of transcription factors has proven to be a powerful approach to understanding embryonic development. Here, we discuss the role of transcription factors in NSC behavior. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cam.3.4.8803?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802757/pdf |
| Ending Page | 424 |
| Page Count | 13 |
| Starting Page | 412 |
| ISSN | 19336918 |
| e-ISSN | 19336926 |
| DOI | 10.4161/cam.3.4.8803 |
| Journal | Cell adhesion & migration |
| Issue Number | 4 |
| Volume Number | 3 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-10-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Adhesion & Migration Developmental Biology Neural Stem Cells Transcription Factors Self-renewal Proliferation Differentiation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cellular and Molecular Neuroscience |
